Chronisch Lymphatische Leukämie Guidline and Quality indicator
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: Population: CLL und Binet Stadium AB - JSON Representation

Active as of 2025-01-16

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{
  "resourceType" : "EvidenceVariable",
  "id" : "PopulationCLLBinetAB",
  "meta" : {
    "profile" : [
      🔗 "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/recommendation-eligibility-criteria"
    ]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: EvidenceVariable PopulationCLLBinetAB</b></p><a name=\"PopulationCLLBinetAB\"> </a><a name=\"hcPopulationCLLBinetAB\"> </a><a name=\"PopulationCLLBinetAB-en-US\"> </a><p><b>url</b>: <a href=\"EvidenceVariable-PopulationCLLBinetAB.html\">EvidenceVariable Population: CLL und Binet Stadium AB </a></p><p><b>name</b>: PopulationCLLBinetAB</p><p><b>title</b>: Population: CLL und Binet Stadium AB </p><p><b>status</b>: Active</p><p><b>date</b>: 2025-01-16 09:02:23+0000</p><p><b>description</b>: </p><div><p>Population, bei der Binet A oder B sowie eine bestimmte klinische Symptomatik vorliegt</p>\n</div><p><b>actual</b>: false</p><blockquote><p><b>characteristic</b></p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: All of</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 404684003}\">Clinical finding (finding)</span></td><td><span title=\"Codes:{http://snomed.info/sct 92814006}\">Chronic lymphoid leukaemia, disease</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: Any of</p><blockquote><p><b>characteristic</b></p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 1149099005}\">Binet staging classification for chronic lymphocytic leukemia</span></td><td><span title=\"Codes:{http://snomed.info/sct 863741000000108}\">Clinical stage A chronic lymphocytic leukaemia</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 1149099005}\">Binet staging classification for chronic lymphocytic leukemia</span></td><td><span title=\"Codes:{http://snomed.info/sct 863761000000109}\">Clinical stage B chronic lymphocytic leukaemia</span></td></tr></table></blockquote></blockquote></blockquote><blockquote><p><b>characteristic</b></p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: Any of</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 404684003}\">Clinical finding (finding)</span></td><td><span title=\"Codes:{http://snomed.info/sct 161832001}\">Weight decreasing</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 404684003}\">Clinical finding (finding)</span></td><td><span title=\"Codes:{http://snomed.info/sct 7520000}\">Pyrexia of unknown origin</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 404684003}\">Clinical finding (finding)</span></td><td><span title=\"Codes:{http://snomed.info/sct 42984000}\">Night sweats</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: All of</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 404684003}\">Clinical finding (finding)</span></td><td><span title=\"Codes:{http://snomed.info/sct 271737000}\">Anemia</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 718-7}\">Hemoglobin [Mass/volume] in Blood</span></td><td><span title=\"Codes:{http://snomed.info/sct 260371004}\">Decreasing</span></td></tr></table></blockquote></blockquote></blockquote><blockquote><p><b>characteristic</b></p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: All of</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 404684003}\">Clinical finding (finding)</span></td><td><span title=\"Codes:{http://snomed.info/sct 302215000}\">Thrombocytopenic disorder</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 26515-7}\">Platelets [#/volume] in Blood</span></td><td><span title=\"Codes:{http://snomed.info/sct 260371004}\">Decreasing</span></td></tr></table></blockquote></blockquote></blockquote><blockquote><p><b>characteristic</b></p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: All of</p><blockquote><p><b>characteristic</b></p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 404684003}\">Clinical finding (finding)</span></td><td><span title=\"Codes:{https://www.medizin.uni-greifswald.de/fhir/guideline/cll/CodeSystem/cll-v2 porecotr}\">Poor response to corticosteroid treatment</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: Any of</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 404684003}\">Clinical finding (finding)</span></td><td><span title=\"Codes:{http://snomed.info/sct 413603009}\">Autoimmune hemolytic anemia</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 404684003}\">Clinical finding (finding)</span></td><td><span title=\"Codes:{http://snomed.info/sct 2897005}\">Immune thrombocytopenia</span></td></tr></table></blockquote></blockquote></blockquote></blockquote></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 404684003}\">Clinical finding (finding)</span></td><td><span title=\"Codes:{https://www.medizin.uni-greifswald.de/fhir/guideline/cll/CodeSystem/cll-v2 sycasp}\">Symptom-causing splenomegaly</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: All of</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 246120007}\">Nodule size</span></td><td>10-?</td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 404684003}\">Clinical finding (finding)</span></td><td><span title=\"Codes:{http://snomed.info/sct 30746006}\">Lymphadenopathy</span></td></tr></table></blockquote></blockquote></blockquote><blockquote><p><b>characteristic</b></p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: All of</p><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 246120007}\">Nodule size</span></td><td><span title=\"Codes:{http://snomed.info/sct 260369004}\">Increasing</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 404684003}\">Clinical finding (finding)</span></td><td><span title=\"Codes:{http://snomed.info/sct 30746006}\">Lymphadenopathy</span></td></tr></table></blockquote></blockquote></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 26474-7}\">Lymphocytes [#/volume] in Blood</span></td><td><span title=\"Codes:{https://www.medizin.uni-greifswald.de/fhir/guideline/cll/CodeSystem/cll-v2 ingrfiftyintwomo}\">Zunahme mehr als 50 Prozent innerhalb von 2 Monaten, gemessen ab einer absoluten Lymphozytenzahl von mindestens 30.000/µl</span></td></tr></table></blockquote><blockquote><p><b>characteristic</b></p><p><b>linkId</b>: CLL</p><h3>DefinitionByTypeAndValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 26474-7}\">Lymphocytes [#/volume] in Blood</span></td><td><span title=\"Codes:{https://www.medizin.uni-greifswald.de/fhir/guideline/cll/CodeSystem/cll-v2 dopeunsixmo}\">Lymphozytenverdopplungszeit unter 6 Monaten, gemessen ab einer absoluten Lymphozytenzahl von mindestens 30.000/µl</span></td></tr></table></blockquote></blockquote></blockquote></blockquote></blockquote></div>"
  },
  "url" : "https://www.medizin.uni-greifswald.de/fhir/guideline/cll/EvidenceVariable/PopulationCLLBinetAB",
  "name" : "PopulationCLLBinetAB",
  "title" : "Population: CLL und Binet Stadium AB ",
  "status" : "active",
  "date" : "2025-01-16T09:02:23+00:00",
  "description" : "Population, bei der Binet A oder B sowie eine bestimmte klinische Symptomatik vorliegt",
  "actual" : false,
  "characteristic" : [
    {
      "definitionByCombination" : {
        "code" : "all-of",
        "characteristic" : [
          {
            "linkId" : "CLL",
            "definitionByTypeAndValue" : {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://snomed.info/sct",
                    "code" : "404684003",
                    "display" : "Clinical finding (finding)"
                  }
                ]
              },
              "valueCodeableConcept" : {
                "coding" : [
                  {
                    "system" : "http://snomed.info/sct",
                    "code" : "92814006",
                    "display" : "Chronic lymphoid leukaemia, disease"
                  }
                ]
              }
            }
          },
          {
            "definitionByCombination" : {
              "code" : "any-of",
              "characteristic" : [
                {
                  "definitionByTypeAndValue" : {
                    "type" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "1149099005",
                          "display" : "Binet staging classification for chronic lymphocytic leukemia"
                        }
                      ]
                    },
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "version" : "http://snomed.info/sct/83821000000107/version/20230412fd",
                          "code" : "863741000000108",
                          "display" : "Clinical stage A chronic lymphocytic leukaemia"
                        }
                      ]
                    }
                  }
                },
                {
                  "definitionByTypeAndValue" : {
                    "type" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "1149099005",
                          "display" : "Binet staging classification for chronic lymphocytic leukemia"
                        }
                      ]
                    },
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "version" : "http://snomed.info/sct/83821000000107/version/20230412fd",
                          "code" : "863761000000109",
                          "display" : "Clinical stage B chronic lymphocytic leukaemia"
                        }
                      ]
                    }
                  }
                }
              ]
            }
          },
          {
            "definitionByCombination" : {
              "code" : "any-of",
              "characteristic" : [
                {
                  "linkId" : "CLL",
                  "definitionByTypeAndValue" : {
                    "type" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "404684003",
                          "display" : "Clinical finding (finding)"
                        }
                      ]
                    },
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "161832001",
                          "display" : "Weight decreasing"
                        }
                      ]
                    }
                  }
                },
                {
                  "linkId" : "CLL",
                  "definitionByTypeAndValue" : {
                    "type" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "404684003",
                          "display" : "Clinical finding (finding)"
                        }
                      ]
                    },
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "7520000",
                          "display" : "Pyrexia of unknown origin"
                        }
                      ]
                    }
                  }
                },
                {
                  "linkId" : "CLL",
                  "definitionByTypeAndValue" : {
                    "type" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "404684003",
                          "display" : "Clinical finding (finding)"
                        }
                      ]
                    },
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "42984000",
                          "display" : "Night sweats"
                        }
                      ]
                    }
                  }
                },
                {
                  "definitionByCombination" : {
                    "code" : "all-of",
                    "characteristic" : [
                      {
                        "linkId" : "CLL",
                        "definitionByTypeAndValue" : {
                          "type" : {
                            "coding" : [
                              {
                                "system" : "http://snomed.info/sct",
                                "code" : "404684003",
                                "display" : "Clinical finding (finding)"
                              }
                            ]
                          },
                          "valueCodeableConcept" : {
                            "coding" : [
                              {
                                "system" : "http://snomed.info/sct",
                                "code" : "271737000",
                                "display" : "Anemia"
                              }
                            ]
                          }
                        }
                      },
                      {
                        "linkId" : "CLL",
                        "definitionByTypeAndValue" : {
                          "type" : {
                            "coding" : [
                              {
                                "system" : "http://loinc.org",
                                "code" : "718-7",
                                "display" : "Hemoglobin [Mass/volume] in Blood"
                              }
                            ]
                          },
                          "valueCodeableConcept" : {
                            "coding" : [
                              {
                                "system" : "http://snomed.info/sct",
                                "code" : "260371004",
                                "display" : "Decreasing"
                              }
                            ]
                          }
                        }
                      }
                    ]
                  }
                },
                {
                  "definitionByCombination" : {
                    "code" : "all-of",
                    "characteristic" : [
                      {
                        "linkId" : "CLL",
                        "definitionByTypeAndValue" : {
                          "type" : {
                            "coding" : [
                              {
                                "system" : "http://snomed.info/sct",
                                "code" : "404684003",
                                "display" : "Clinical finding (finding)"
                              }
                            ]
                          },
                          "valueCodeableConcept" : {
                            "coding" : [
                              {
                                "system" : "http://snomed.info/sct",
                                "code" : "302215000",
                                "display" : "Thrombocytopenic disorder"
                              }
                            ]
                          }
                        }
                      },
                      {
                        "linkId" : "CLL",
                        "definitionByTypeAndValue" : {
                          "type" : {
                            "coding" : [
                              {
                                "system" : "http://loinc.org",
                                "code" : "26515-7",
                                "display" : "Platelets [#/volume] in Blood"
                              }
                            ]
                          },
                          "valueCodeableConcept" : {
                            "coding" : [
                              {
                                "system" : "http://snomed.info/sct",
                                "code" : "260371004",
                                "display" : "Decreasing"
                              }
                            ]
                          }
                        }
                      }
                    ]
                  }
                },
                {
                  "definitionByCombination" : {
                    "code" : "all-of",
                    "characteristic" : [
                      {
                        "definitionByTypeAndValue" : {
                          "type" : {
                            "coding" : [
                              {
                                "system" : "http://snomed.info/sct",
                                "code" : "404684003",
                                "display" : "Clinical finding (finding)"
                              }
                            ]
                          },
                          "valueCodeableConcept" : {
                            "coding" : [
                              {
                                "system" : "https://www.medizin.uni-greifswald.de/fhir/guideline/cll/CodeSystem/cll-v2",
                                "code" : "porecotr",
                                "display" : "Poor response to corticosteroid treatment"
                              }
                            ]
                          }
                        }
                      },
                      {
                        "definitionByCombination" : {
                          "code" : "any-of",
                          "characteristic" : [
                            {
                              "linkId" : "CLL",
                              "definitionByTypeAndValue" : {
                                "type" : {
                                  "coding" : [
                                    {
                                      "system" : "http://snomed.info/sct",
                                      "code" : "404684003",
                                      "display" : "Clinical finding (finding)"
                                    }
                                  ]
                                },
                                "valueCodeableConcept" : {
                                  "coding" : [
                                    {
                                      "system" : "http://snomed.info/sct",
                                      "code" : "413603009",
                                      "display" : "Autoimmune hemolytic anemia"
                                    }
                                  ]
                                }
                              }
                            },
                            {
                              "linkId" : "CLL",
                              "definitionByTypeAndValue" : {
                                "type" : {
                                  "coding" : [
                                    {
                                      "system" : "http://snomed.info/sct",
                                      "code" : "404684003",
                                      "display" : "Clinical finding (finding)"
                                    }
                                  ]
                                },
                                "valueCodeableConcept" : {
                                  "coding" : [
                                    {
                                      "system" : "http://snomed.info/sct",
                                      "code" : "2897005",
                                      "display" : "Immune thrombocytopenia"
                                    }
                                  ]
                                }
                              }
                            }
                          ]
                        }
                      }
                    ]
                  }
                },
                {
                  "linkId" : "CLL",
                  "definitionByTypeAndValue" : {
                    "type" : {
                      "coding" : [
                        {
                          "system" : "http://snomed.info/sct",
                          "code" : "404684003",
                          "display" : "Clinical finding (finding)"
                        }
                      ]
                    },
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "https://www.medizin.uni-greifswald.de/fhir/guideline/cll/CodeSystem/cll-v2",
                          "code" : "sycasp",
                          "display" : "Symptom-causing splenomegaly"
                        }
                      ]
                    }
                  }
                },
                {
                  "definitionByCombination" : {
                    "code" : "all-of",
                    "characteristic" : [
                      {
                        "linkId" : "CLL",
                        "definitionByTypeAndValue" : {
                          "type" : {
                            "coding" : [
                              {
                                "system" : "http://snomed.info/sct",
                                "code" : "246120007",
                                "display" : "Nodule size"
                              }
                            ]
                          },
                          "valueRange" : {
                            "low" : {
                              "value" : 10,
                              "system" : "http://unitsofmeasure.org",
                              "code" : "cm"
                            }
                          }
                        }
                      },
                      {
                        "linkId" : "CLL",
                        "definitionByTypeAndValue" : {
                          "type" : {
                            "coding" : [
                              {
                                "system" : "http://snomed.info/sct",
                                "code" : "404684003",
                                "display" : "Clinical finding (finding)"
                              }
                            ]
                          },
                          "valueCodeableConcept" : {
                            "coding" : [
                              {
                                "system" : "http://snomed.info/sct",
                                "code" : "30746006",
                                "display" : "Lymphadenopathy"
                              }
                            ]
                          }
                        }
                      }
                    ]
                  }
                },
                {
                  "definitionByCombination" : {
                    "code" : "all-of",
                    "characteristic" : [
                      {
                        "linkId" : "CLL",
                        "definitionByTypeAndValue" : {
                          "type" : {
                            "coding" : [
                              {
                                "system" : "http://snomed.info/sct",
                                "code" : "246120007",
                                "display" : "Nodule size"
                              }
                            ]
                          },
                          "valueCodeableConcept" : {
                            "coding" : [
                              {
                                "system" : "http://snomed.info/sct",
                                "code" : "260369004",
                                "display" : "Increasing"
                              }
                            ]
                          }
                        }
                      },
                      {
                        "linkId" : "CLL",
                        "definitionByTypeAndValue" : {
                          "type" : {
                            "coding" : [
                              {
                                "system" : "http://snomed.info/sct",
                                "code" : "404684003",
                                "display" : "Clinical finding (finding)"
                              }
                            ]
                          },
                          "valueCodeableConcept" : {
                            "coding" : [
                              {
                                "system" : "http://snomed.info/sct",
                                "code" : "30746006",
                                "display" : "Lymphadenopathy"
                              }
                            ]
                          }
                        }
                      }
                    ]
                  }
                },
                {
                  "linkId" : "CLL",
                  "definitionByTypeAndValue" : {
                    "type" : {
                      "coding" : [
                        {
                          "system" : "http://loinc.org",
                          "code" : "26474-7",
                          "display" : "Lymphocytes [#/volume] in Blood"
                        }
                      ]
                    },
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "https://www.medizin.uni-greifswald.de/fhir/guideline/cll/CodeSystem/cll-v2",
                          "code" : "ingrfiftyintwomo",
                          "display" : "Zunahme mehr als 50 Prozent innerhalb von 2 Monaten, gemessen ab einer absoluten Lymphozytenzahl von mindestens 30.000/µl"
                        }
                      ]
                    }
                  }
                },
                {
                  "linkId" : "CLL",
                  "definitionByTypeAndValue" : {
                    "type" : {
                      "coding" : [
                        {
                          "system" : "http://loinc.org",
                          "code" : "26474-7",
                          "display" : "Lymphocytes [#/volume] in Blood"
                        }
                      ]
                    },
                    "valueCodeableConcept" : {
                      "coding" : [
                        {
                          "system" : "https://www.medizin.uni-greifswald.de/fhir/guideline/cll/CodeSystem/cll-v2",
                          "code" : "dopeunsixmo",
                          "display" : "Lymphozytenverdopplungszeit unter 6 Monaten, gemessen ab einer absoluten Lymphozytenzahl von mindestens 30.000/µl"
                        }
                      ]
                    }
                  }
                }
              ]
            }
          }
        ]
      }
    }
  ]
}